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Int Urol Nephrol (2012) 44:515521 DOI 10.1007/s11255-011-9963-4
NEPHROLOGY ORIGINAL PAPER
Relationship of glomerular ltration rate and serum CK activity after resistance exercise in women
Marco Machado Elida N. Zini
Samara D. Valado Mayra Z. Amorim
Tiago Z. Barroso Wilkes de Oliveira
Received: 11 January 2011 / Accepted: 30 March 2011 / Published online: 20 April 2011 Springer Science+Business Media, B.V. 2011
Abstract The aim of study was to assess the correlation between the changes in serum CK activity after a resistance exercise and renal function measured by glomerular ltration rate (eGFR). Twenty-nine trained women (32 10 years; 157 4 cm; 58.8 6.4 kg) performed a resistance exercise session with 17 exercises with 3 9 12 repetitions in a circuit training fashion. Subjects provided blood samples prior to exercise session (PRE), and at 24, 48, and 72 h following exercise session for creatine kinase (CK) and creatinine. 24-Urine samples were collected before and 72 h after exercises. eGFR was obtained by the three most recommended methods (MDRD; MCQE; Cockcroft-Gault). After the exercise session, serum CK activity increase up 1.68 times (P \ 0.01). Serum creatinine increased 25.5% (P = 0.0000) while uri-nary creatinine decreased on average 6.4% (P =0.0422). eGFR decreased in all formulas: MDRD by21.5%, MCQE by 14.2%, and C-G by 17% (all with P \ 0.01). Ccr also decreased (-22.9%, P \ 0.01).
The index of correlation was signicant for MDRD
(r = -0.924; P \ 0.01), C-G (r = -0.884; P \0.01), and MQCE (r = -0.644; P \ 0.05). In conclusion, we observed a signicant negative correlation between CK activity and the eGFR indices of renal function.
Keywords Skeletal muscle micro-trauma
Muscular stress Biochemical markers Kidney
Creatinine
Introduction
Strenuous, overexertion exercise can result in muscle damage evidenced by delayed-onset muscle soreness, strength loss, weakness, tenderness, and increased blood levels of muscle proteins such as creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin (Mb) [1, 2]. Exertional Rhabdomyolysis (ERB) is a clinical condition where excessive muscle damage can lead to renal failure [2]. Although CK and other intramuscular proteins (LDH, aspartate aminotransferase, alanine aminotransferase) are cleared from the blood by the reticuloendothelial system, myoglobin is cleared by the kidneys. High blood myoglobin levels can spill over into the urine, resulting in myoglobinuria and...