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ABSTRACT:
Solid lipid nanoparticles (SLN) are the emerging field of nanotechnology having many potential applications in drug delivery as well as in research. Lipid nanoparticles offer possibility to develop new therapeutics due to their unique size dependent properties. The ability of incorporating drug molecules into nanocarriers provides a new prototype in drug Delivery which could be used for drug targeting. Therefore solid lipid nanoparticles have great promise for increasing the goal of controlled and site specific drug delivery. Present review focus on broad treatment of solid lipid nanoparticles with their aims, production procedures, advantages, limitations and their possible remedies. SLN are sub-micron colloidal carriers ranging from 50 to 1000 nm, which are composed of physiological lipid, dispersed in water or in aqueous surfactant solution. Solid lipid nanoparticle offer unique properties such as very small size, large surface area, high drug loading and the interaction of phases at the interface and are attractive for their potential to increase performance of pharmaceuticals.
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INTRODUCTION:
Solid lipid nanoparticles (SLN) are introduced in the year of 1991 an alternative carrier system. Tradition colloidal carriers system such as - emulsions, liposome's and polymeric micro - and nanoparticles. Hence nanoparticles made from solid lipids are attracting major attention as novel colloidal drug carrier system for intravenous applications also they have been proposed as an alternative particulate carrier system. SLN are submicron colloidal carriers ranging from 50 to 1000 nm, which are composed of physiological lipid, dispersed in water or in aqueous surfactant solution. Solid lipid nanoparticle offer unique properties such as very small size, large surface area, high drug loading and the interaction of phases at the interface and are attractive for their potential to increase performance of pharmaceuticals.
Solid lipid nanoparticles are one of the modern potential colloidal carrier system as alternative materials to excipients which is identical to oil in water emulsion for parenteral nutrition. They have many advantages such as good biocompatibility, low toxicity and lipophilic drugs are better delivered by solid lipid nanoparticles and the system is physically stable.
Advantages of SLN 1-4
* Control or target drug release.
* Good biocompatibility.
* Increase stability of pharmaceuticals.
* High and enhanced drug content.
* Easy to scale up and sterilize.
* Better control over release...