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ABSTRACT:
Transdermal patches deliver the drug through the skin in a controlled and predetermined manner in order to increase the therapeutic efficacy of drug. Rizatriptan a 2nd generation triptan that has a favorable tolerability profile and patients have reported greater satisfaction. The aim of the present work was to formulate and evaluate transdermal patches of Rizatriptan. For the current study, the transdermal patch containing drug with different ratios of polymeric combinations and varying plasticizer concentration were prepared. The patch was fabricated by solvent casting method. The casting solvents and plasticizers used were ethanol and propylene glycol respectively. The polymers used were HPMC, PVP and EC. The fabricated patches were evaluated for its physicochemical study. From the studies it concluded that F5 (EC and HPMC of 1:4 ratio and plasticizer 2 ml) whose thickness 0.124 mm, weight variation 110 mg, folding endurance 328 times, percentage moisture absorption of 5%, tensile strength of 0.78 kg/cm2, drug content of 90.42 % and in vitro drug release of 96.3 % may be selected as the optimized formulation. The released kinetics of the optimized formulation follows first order. It can be concluded that it is possible to fabricate a transdermal delivery of Rizatriptan for treatment migraine where the patient acceptance and tolerability profile is high.
KEYWORDS: Rizatriptan, Transdermal Patches, HPMC, Ethyl Cellulose.
(ProQuest: ... denotes formulae omitted.)
INTRODUCTION:
Transdermal patches deliver the medicament through the skin in a controlled and predetermined manner in order to increase the therapeutic efficacy of drug and reduced side effect of drug. It delivers the drug via skin portal to systemic circulation at a predetermined rate over a prolonged period with a specific amount of dose. Success of a transdermal patch depends on a variety of biological, physiological, biochemical and biophysical factors. It depends on the composition, integrity and thickness of the stratum corneum. The structure and size of the molecule are indicators of diffusivity. It depends on the permeability of the membrane in the transdermal drug delivery system, state of skin hydration pH and other physiochemical drug properties.
Lipophillicity of the drug, degree of partitioning of the drug and associated components are also essential. Presently this method of drug delivery has the most potential than other routes of administration because it avoids problems...