Content area
Full text
Exp Brain Res (2014) 232:723738 DOI 10.1007/s00221-013-3818-4
REVIEW
The role of serotonin in memory: interactions with neurotransmitters and downstream signaling
Mohammad Seyedabadi Gohar Fakhfouri Vahid Ramezani Shahram Ejtemaei Mehr Reza Rahimian
Received: 28 April 2013 / Accepted: 20 December 2013 / Published online: 16 January 2014 Springer-Verlag Berlin Heidelberg 2014
there has been an alteration in the density of serotonergic receptors in aging and Alzheimers disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways.
Keywords Serotonin Memory Signaling pathways
Abbreviations
2PSDT Two-platform spatial discrimination task 3xTg-AD Triple-transgenic mouse model of Alzheimers disease5-HT 5-HydroxytryptamineAC Adenylate cyclaseAch AcetylcholineAD Alzheimers diseaseAPP Amyloid precursor proteinARN Anterior raphe nucleusA AmyloidcAMP Cyclic adenosine monophosphatecGMP Cyclic guanosine monophosphateCPP Conditioned place preferenceCREB cAMP-response element bindingDA DopamineDH Dorsal hippocampusDMTS Delayed matching to sampleDNPTP Delayed non-matching to positionDRN Dorsal raphe nucleusEPAC
Exchange proteins activated by cAMP EPSCs Excitatory postsynaptic currentsERK Extracellular signal-regulated kinase FC Frontal cortex
Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT17), each with several subpopulations, have been identied for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, -aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition,
M. Seyedabadi
Department of Molecular Imaging, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
G. Fakhfouri
Department of Psychiatry and Neuroscience, Universit Laval, Quebec, QC, Canada
G. Fakhfouri
Institut Universitaire en Sant Mentale de Qubec (IUSMQ) Research Center, Quebec, QC, Canada
V. Ramezani
Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
S. E. Mehr R. Rahimian (*)
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P. O. Box 13145-784,...