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Abstract
The measurement of specific salivary enzyme activity may be valuable in the diagnosis of human periodontal disease. Alkaline phosphatase has often been measured as possible indicators of gingival inflammation and bone metabolism. It has been found that untreated adult periodontitis patients exhibited higher level of alkaline phosphatase in whole saliva than did healthy control. Alkaline phosphatase levels change in relation to gingival inflammation and bone loss. 30subjects (each having at least 20 teeth) in the age18-55 years (10 subjects with healthy periodontium, 10 with generalized gingivitis and 10 with generalized periodontitis) were randomly selected. Unstimulated whole saliva collected from each subject was transferred to auto analyzer to measure the salivary alkaline phosphatase levels. The quantitative analysis of salivary alkaline phosphatase levels of samples obtained from subjects with healthy periodontium, generalized gingivitis, generalized periodontitis showed, 18.50±5.07 IU, 39.49± 9.97IUand 85.18±16.85IU (mean± standard deviation), respectively. The present results showed the potential value of salivary alkaline phosphatase level as indicator for periodontal disease status. [PUBLICATION ABSTRACT]