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Int Ophthalmol (2010) 30:495500 DOI 10.1007/s10792-010-9386-8
ORIGINAL PAPER
Sensitivity of laser are photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inammation in uveitis
Ottavio Bernasconi Marina Papadia
Carl P. Herbort
Received: 29 April 2010 / Accepted: 10 July 2010 / Published online: 5 August 2010 Springer Science+Business Media B.V. 2010
Abstract To study the sensitivity of laser are photometry (LFP) in monitoring anterior chamber inammation by correlating LFP measurements with slit-lamp evaluation of aqueous cells in HLA-B27-related uveitis in a prospective trial. Slit-lamp cell evaluation was correlated with LFP-measured are in a masked fashion in HLA-B27-related uveitis patients receiving standard topical therapy. At the time of 50 and 90% LFP are reduction, the corresponding reduction of cells was recorded and statistically
compared using the sign test. Forty-three episodes (in 43 patients) of acute anterior HLA-B27-related uveitis were included. LFP are reduction and slit-lamp cell reduction were strongly correlated. LFP was signicantly more sensitive for both 50% (P =0.001) and 90% (P = 0.02) LFP are reduction in assessing the decrease of anterior chamber inammation. LFP was superior to slit-lamp cell evaluation in monitoring anterior chamber inammation in uveitis. Flare, becoming a quantitative parameter when measured by LFP, rather than cells, should be considered the gold standard to measure anterior chamber inammation in uveitis.
Keywords Laser are photometry
Intraocular inammation Quantitative method
Introduction
In 1959, a standardization system for the evaluation of intra-ocular inammatory activity in uveitis was established and has been almost universally used for more than 40 years [1, 2]. In 2004 a panel of uveitis specialists that convened to establish new universal criteria for the standardization of uveitis nomenclature (SUN) re-adopted this grading system essentially unchanged despite the fact that laser are photometry (LFP), a precise new technology for the grading of intra-ocular inammation had been available for
The results presented here apply only to slit-lamp models of aremeters (Kowa FC-1000, Kowa FC-2000 and Kowa FM-500), but cannot be extrapolated to the FM-600 model which is ill-suited for use in uveitis.
O. Bernasconi M. Papadia C. P. Herbort (&)
Inammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialised Care (COS), Rue de la Grotte, 1003 Lausanne, Switzerland e-mail: [email protected]
O. BernasconiOspedale Regionale Bellinzona e Valli, Bellinzona, Switzerland
M. PapadiaDepartment of Neurosciences,...