Serum Lactic Acid and Pyruvic Acid Levels in Patients with Migraine and Tension Type Headache

Headnote

ABSTRACT

Serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache

Objective: MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is frequently associated with migraine like headaches. The relationship between migraine and mitochondrial diseases is interesting. Also mitochondrial disorders in tension like headache still remain to be investigated. The aim of this report is to evaluate the serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache and compare them with healthy control group.

Methods: We evaluated 30 patients with migraine, 30 patients with tension like headache and 30 healthy control. Lactic and pyruvic acid levels in serum samples were measured by biochemical methods. Kruskal Wallis and Mann-Whitney tests were used for statistical analysis using SPSS 11.5 for Windows program.

Results: Serum lactic and pyruvic acid levels in patients with migraine and tension type headache were significantly higher than control group.

Conclusion: Multi-disciplinary researches are needed to determine mitochondrial diseases in patients with migraine and tension like headache.

Key words: MELAS, migraine, mitochondrial diseases, lactic acid, pyruvic acid

ÖZET

Migren tipi ve gerilim tipi ba? a?r?lar? bulunan hastalarda pirüvik ve laktik asit seviyeleri

Amaç: Bir mitokondriyal sitopati olan MELAS (Mitokondriyal miyopati, ensefalopati, laktik asidoz ve inme benzeri epizotlar) sendromuna migren tipi ba? a?r?lar? s?kl?kla e?lik eder. Bu nedenle, migren ile mitokondriyal bozukluklar aras?ndaki ili?ki ilgi çekicidir. Ayr?ca gerilim tipi ba? a?r?lar?nda da mitokondriyal anormallikler incelenmektedir. Biz de migrenli ve gerilim tipi ba? a?r?lar?nda mitokondriyal bozukluk varl???n? ara?t?rmak amac?yla serum laktik ve pirüvik asit düzeylerini ölçmeyi ve bu de?erleri sa?l?kl? kontrol grubuyla kar??la?t?rmay? amaçlad?k.

Yöntem: Çal??maya, Uluslararas? Ba? A?r?s? Toplulu?u'nun (IHS) 2004 s?n?flama sistemine göre tan? alm?? 30 migrenli, 30 gerilim tipi ba? a?r?l? hasta ve 30 sa?l?kl? kontrol al?nd?. Çal??maya kat?lanlardan al?nan örneklerde serum laktik ve pirüvik asit düzeyleri biyokimyasal yöntemlerle çal???ld?. ?statistiksel analizler için SPSS program?nda Kruskal-Wallis Testi ve Mann-Whitney testleri kullan?ld?.

Bulgular: Migren ve gerilim tipi ba? a?r?s? olan hastalar?n serum laktik ve pirüvik asit düzeyleri, kontrol grubuyla kar??la?t?r?ld???nda anlaml? olarak yüksek bulundu.

Sonuç: Migrenli ve gerilim tipi ba? a?r?l? hastalarda mitokondriyal bozukluklar?n ara?t?r?lmas? için geni? çapl? multidisipliner ara?t?rmalar gereklidir.

Anahtar kelimeler: MELAS, migren, mitokondriyal bozukluklar, laktik asit, pirüvik asit

INTRODUCTION

n recent years, the research on migraine pathophysiology focused...