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Ann Hematol (2009) 88:913915 DOI 10.1007/s00277-008-0668-4
LETTER TO THE EDITOR
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in select chronic diseases
Geon Park & Chi Young Park & Sook Jin Jang &
Dae Soo Moon & Sang Muk Park & Young Jin Park
Received: 30 May 2008 /Accepted: 6 December 2008 / Published online: 10 January 2009 # Springer-Verlag 2009
Dear Editor,This paper reports valuable parameters, soluble transferrin receptor-ferritin index (sTfR-F) and estimated body iron (EBI), to make the diagnosis of iron deficiency anemia (IDA) in chronic diseases. Based on the textbook definition [1], anemia of chronic diseases do not include anemia caused by bone marrow replacement, blood loss, renal failure, hepatic diseases, hemolysis, and endocrine deficiencies and so those diseases were excluded in this study. In addition, to obtain a high efficiency in detecting IDA from chronic diseases, the patients were limited to those with select chronic diseases excluding pernicious anemia, parvovirus
B19, and hematologic malignancies. The select chronic diseases were arbitrary made for this study. Those patients were admitted to Chosun University Hospital. One hundred seventy-seven patients with select chronic diseases, including 27 patients with chronic infections, 71 patients with chronic diseases, and 79 patients with non-hematologic malignancies, were studied. The male female ratio was variable and the ages ranged from 18 81 years. All patients were divided into three disease groups according to the criteria for anemia and IDA (below described). Thus, there were 48 patients with non-anemic state in select chronic diseases (NAsCD group), 110 patients with anemia of select chronic diseases (AsCD group), and 19 patients with IDA in select chronic diseases (IDA-sCD group). The criterion for anemia was a hemoglobin <13.0 g/L in males and <12.0 g/L in females in the peripheral blood. The criteria for IDA were the presence of anemia, MCV <80 fL, MCHC <32 g/L, RDW >17%, and concurrent microcytic hypochromic RBC with anisocytosis on the peripheral blood smear....