Content area
Full Text
Anthony L. Petraglia. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Benjamin A. Plog. 2 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Samantha Dayawansa. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Michael Chen. 2 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Matthew L. Dashnaw. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Katarzyna Czerniecka. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Corey T. Walker. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Tyler Viterise. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Ollivier Hyrien. 3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York.
Jeffrey J. Iliff. 4 Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon.
Rashid Deane. 2 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Maiken Nedergaard. 2 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Jason H. Huang. 1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
Address correspondence to: Anthony L. Petraglia, MD, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, E-mail: [email protected]
Introduction
There has been increasing attention focused on the neurological sequelae of sports-related traumatic brain injury (TBI), particularly concussion and subconcussion.1,2 In the United States alone, an estimated 3.8 million sports- and recreation-related concussions occur each year.3 Most studies have focused on moderate and severe TBI (sTBI), but concussive and subconcussive head injuries affect more people, occur more frequently, and are a silent epidemic of increasing importance.2,4 Additionally, there is a greater appreciation that repetitive mild TBI (mTBI) may lead to detrimental effects on neurological function both short and long term, including the potential for chronic neurodegenerative syndromes, such as Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, and chronic traumatic encephalopathy (CTE).