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Int Ophthalmol (2007) 27:117123 DOI 10.1007/s10792-006-9001-1
ORIGINAL PAPER
The spectrum of Vogt-Koyanagi-Harada disease in Turkey
VKH in Turkey
Ilknur Tugal-Tutkun Yilmaz Ozyazgan Yonca A. Akova Yuksel Sullu Nurettin Akyol Merih Soylu Haluk Kazokoglu
Received: 15 March 2006 / Accepted: 8 June 2006 / Published online: 7 September 2006 Springer Science+Business Media B.V. 2006
Abstract Aim The aim of this report was to provide a detailed description of the clinical features of Vogt-Koyanagi-Harada (VKH) disease in Turkish patients.Methods We retrospectively analyzed 45 patients diagnosed with VKH disease at seven referral centers in Turkey. A standard data acquisition form was used for the analysis of demographic and clinical features. Results The study cohort consisted of 45 patients (32 female, 13 male) who had a mean age at presentation of 31 years. Seven patients (15%) were aged 16 years or younger. Nineteen (42%) patients presented in the acute or subacute stage and 26 (58%) in the chronic stage. According to the revised diagnostic criteria, nine (20%) patients
had the complete form of the disease, 23 (51%) had the incomplete form, and 13 (29%) had probable VKH disease. All patients had bilateral ocular involvement. Sunset-glow fundus was ob-served in 89% of the patients, pigment clumping in 73%, nummular depigmented scars in 71%, cataract in 53%, optic atrophy in 31%, glaucoma in 29%, subretinal brosis in 22%, choroidal neovascular membranes in 7%, and phthisis in 4%. All patients who presented at the acute uveitic stage received systemic corticosteroid therapy. Immunosuppressive treatment was employed in 30 (66%) patients, which was initiated at the acute uveitic stage in ten (22%) patients. Final visual acuity was better than 0.5 in 59% of the patients eyes, between 0.1 and 0.5 in 21%, and less than 0.1 in 20%.
I. Tugal-Tutkun Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
I. Tugal-Tutkun (&)
Istanbul Tip Fakultesi, Goz Hast. A.D. CAPA, 34390 Istanbul, Turkeye-mail: [email protected]
Y. OzyazganDepartment of Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
Y. A. AkovaDepartment of Ophthalmology, Faculty of Medicine, Bas kent University, Ankara, Turkey
Y. SulluDepartment of Ophthalmology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
N. AkyolDepartment of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
M. SoyluDepartment of Ophthalmology, Faculty of Medicine, Cukurova University, Adana,...