Content area
Abstract
In a subgroup of TOPCAT participants assigned to spironolactone, the spironolactone metabolite canrenone was measured to assess adherence. Canrenone levels were undetectable in 30% of participants from Russia, as compared with only 3% from the United States and Canada.
Details
Title
Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation
Author
de Denus Simon; O’Meara Eileen 1 ; Desai, Akshay S; Claggett, Brian; Lewis, Eldrin F 2 ; Leclair Grégoire; Jutras, Martin 3 ; Lavoie Joël 1 ; Solomon, Scott D 2 ; Pitt Bertram 4 ; Pfeffer, Marc A 2 ; Rouleau, Jean L 1
1 Montreal Heart Institute, Montreal, QC, Canada
2 Brigham and Women’s Hospital, Boston, MA
3 Université de Montréal, Montreal, QC, Canada
4 University of Michigan School of Medicine, Ann Arbor, MI
1 Montreal Heart Institute, Montreal, QC, Canada
2 Brigham and Women’s Hospital, Boston, MA
3 Université de Montréal, Montreal, QC, Canada
4 University of Michigan School of Medicine, Ann Arbor, MI
Pages
1690-1692
Section
Correspondence
Publication year
2017
Publication date
Apr 27, 2017
Website
ISSN
00284793
e-ISSN
15334406
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1892749709
Copyright
Copyright © 2017 Massachusetts Medical Society. All rights reserved.