STABILITY STUDIES AND METHOD FOR ENHANCEMENT OF LIPOSOMES

Abstract

The main method for determining the storage requirements and expiration dates for pharmaceutical items is stability testing. For stability testing, a variety of techniques have been employed, but the majority of the industry is now standardising on the guidelines provided by the International Conference on Harmonization. Regulating bodies and business representatives from Europe, Japan, and the US worked together to produce these standards. Obtaining relevant and reliable stability data requires careful study planning, execution, monitoring, and assessment. Stability studies are important for the establishment and guarantee of the drug product's safety, quality, and efficacy from the early stages of development through its entire lifespan.For medication delivery, drug targeting, controlled release, and increasing solubility, liposomes have been thoroughly studied. This flexible drug delivery system's instability is a key barrier to its wide-scale usage. The methods discussed in the current review, which include controlling particle size, lipid composition, drug loading technique, prodrugs, pro-liposomes, and lyophilization, are meant to improve the liposomes' overall physical, chemical, and biological stabilities because they are all interconnected