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A study that compared the speed and efficacy of haloperidal (Haldol) and clonazepam (Klonopin) in 16 patients showed that although clonazepam did not work as swiftly as haloperidal, it proved similarly effective in quelling manic symptoms within 2 hours after administration.
The acutely manic psychotic patients were randomized to receive three injections of haloperidol (5 to 10 mg) or cfonazepam (1 to 2 mg) at half-hour intervals....