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In September 2003 the United Kingdom's Committee on Safety of Medicines and the Medicines and Healthcare products Regulatory Agency highlighted the possible interaction between warfarin and cranberry juice and advised patients taking warfarin to limit or avoid drinking cranberry juice.1 They had received 8 reports since 1999 of a possible interaction that led to changes in the international normalized ratio (INR) or bleeding: in 1 case the patient died, in 4 cases there was an increase in INR or bleeding, in 2 cases the INR was unstable, and in 1 case the INR decreased.2 In the fatal case, the patient's previously stable INR increased to > 50 (therapeutic INR 2.0-3.0) following 6 weeks of cranberry juice consumption.2 The patient died of a gastrointestinal and pericardial hemorrhage. In another case a patient with a prosthetic mitral valve was taking warfarin....