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Applied kinesiology evaluates structural, chemical, and mental aspects of health using manual muscle testing (MMT) alongside conventional diagnostic methods to identify dysfunctional areas producing neural dysafferentation. Therapy localization (TL), strictly diagnostic, demonstrates a change of muscle facilitation when the patient's hand is placed over an area of suspected involvement, thought to involve the cutaneomotor receptors and reflexes. To confirm both the reliability and validity of facilitated (strong) and inhibited (weak) muscle reflexes, 15 asymptomatic subjects and 21 patients experiencing neck or shoulder pain for at least two days prior were subjected to MMT of the middle deltoid muscle of the right arm by three examiners and connected to sensors, an electrogoniometer, and amplifier to determine force, changes in motion, and vibromyography (VMG) accompanying the muscle tests. Patients were seated with the head and neck in a neutral position. Chi- Square analyses of the diagnoses revealed strong agreement between clinicians in weak and strong MMT determinations, as well as significant differences between weak and strong MMT in the absence or presence of TL. The presence of TL was correlated with injuries. Instrumentation revealed that (a) there were no significant differences in the force applied by clinicians under all conditions, and (b) there were significant differences between weak and strong MMT in the presence or absence of TL, as shown by both electrogoniometry and VMG.