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ABSTRACT
Objective: In the present study, it was aimed to examine thyroid functions in a group of patients with obsessive compulsive disorder (OCD) who had not any comorbid conditions. Methods: Our present study included forty patients diagnosed with OCD and forty healthy controls. The subjects were selected by the chart reviews among the patients with OCD who had applied to the Firat University School of Medicine Department of Psychiatry, as inpatients or outpatients and had met the criteria of the present investigation. Thyroid hormone values had been obtained by using an auto analyzer. Results: Independent t test revealed that there were no statistically significant differences thyroid stimulating hormone (TSH) values between the patients with OCD and healthy control subjects whereas there were statistically significant reduced levels of free triiodothyronine (FT3) and free thyroxine (FT4) hormones in the patient group compared to those of healthy ones. Conclusion: Consequently, altered levels of thyroid hormones may be associated with pathophysiology or at least maintenance of OCD. (Anatolian Journal of Psychiatry 2016; 17(2):99-103)
Key words: OCD, TSH, thyroid hormones
ÖZET
Amaç: Çalismamizda, komorbid durumu olmayan obsesif kompulsif bozukluklu (OKB) bir grup hastada tiroid islevlerinin incelenmesi amaçlanmistir. Yöntem: Çalismaya 40 OKB hastasi ve 40 saglikli kontrol grubu alindi. Denekler, Firat Üniversitesi Tip Fakültesi Psikiyatri Bölümü'nde ayaktan veya yatarak tedavi gören ve çalisma ölçütlerini karsilayan OKB hastalarinin dosyalarinin geriye dönük taranmasiyla seçildi. Tiroid hormon degerleri auto-analizer kullanilarak elde edildi. Bulgular: Bagimsiz t testi, tiroid salgilatici hormon (TSH) düzeylerinin OKB grubu ile saglikli kontrol grubu arasinda istatistiksel olarak anlamli fark olmadigini, serbest triiyodotironin ve sebest tiroksin düzeylerinin ise hasta grubunda, kontrol grubuna göre istatistiksel olarak anlamli düzeyde azaldigini ortaya koymustur. Sonuç: Sonuç olarak, tiroid hormonlarinin düzeylerindeki degisiklik, OKB'nin patofizyolojisiyle veya en azindan hastaligin kliniginin sürmesiyle iliskili olabilir. (Anadolu Psikiyatri Dergisi 2016 17(2):99-103)
Anahtar sözcükler: OKB, TSH, tiroid hormonlari
INTRODUCTION
Obsessive compulsive disorder (OCD) is char-acterized by obsessions and compulsions. Obsessions are unwanted intrusive thoughts that lead to a significant distress. Compulsions are repetitive behaviors or mental actions that exert to neutralize obsessional thoughts. In Diagnostic and Statistical Manual of Mental Disorders 4th Text Revised version, it is classi- fied in anxiety disorders. Although an important amount of attempts has been performed on exploring the pathogenesis of OCD, the exact reason...