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The fully human lgG2 antibody ticilimumab* failed to demonstrate any benefit on overall survival as first-line treatment of patients with metastatic melanoma in a phase III study. These results were presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO).
A total of 655 patients with unresectable stage IIIc-IV melanoma without brain metastasis were randomised to receive either IV ticilimumab 15 mg/kg...