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METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Weigh and/or measure each ingredient accurately.
3. Mix the tretinoin, PEG 400, Cremophor RH400, and butylated hydroxytoluene together and heat to about 40°C.
4. Add the dexpanthenol and purified water and mix well and heat to about 50°C.
5. Add about 4 g of the Pluronic F-127 and mix well.
6. Cool to about 5°C to 8°C and dissolve the rest of the Pluronic F-127.
7. Keep cool until all air bubbles have escaped.
8. Package and label.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed.
STABILITY
A beyond-use date of up 6 months can be used for this preparation.1
USE
Tretinoin and dexpanthenol gel has been used in the treatment of dermatological conditions, including skin neoplasm and actinic keratoses.
QUALITY CONTROL
Quality-control assessment can include theoretical weight compared to actual weight, pH, specific gravity, active drug assay, color, texture-surface, texture-spatula spread, appearance, feel, rheological properties, and physical observations.2
DISCUSSION
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