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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in H. pylori-mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in H. pylori pathogenesis are summarized.

Details

Title
Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
Author
Chichirau, Bianca E 1 ; Diechler, Sebastian 1 ; Posselt, Gernot 1   VIAFID ORCID Logo  ; Wessler, Silja 2   VIAFID ORCID Logo 

 Department of Biosciences, Paris-Lodron University of Salzburg, 5020 Salzburg, Austria; [email protected] (B.E.C.); [email protected] (S.D.); [email protected] (G.P.) 
 Cancer Cluster Salzburg, Department of Biosciences, Paris-Lodron University of Salzburg, 5020 Salzburg, Austria 
First page
591
Publication year
2019
Publication date
2019
Publisher
MDPI AG
e-ISSN
20726651
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2550280825
Copyright
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.