Abstract

Abstract

Synthetic cathinones are a class of psychoactive drugs that have become, in recent years, of quite common observation in medical and toxicological forensic field. MDPHP (3,4-methylenedioxy-α-pyrrolidinohexanophenone) belongs to this class of substances but lethal acute intoxication caused by this specific substance without other co-ingestions has never been described in literature. We are presenting the unique case of a fatal acute intoxication caused by MDPHP in a 48-year-old man carried to the A&E department of a big Milanese hospital where he suddenly deceased after brief time. Clinical records, autopsy examination, histological findings, and toxicological analysis, assessed via a Q-Exactive Orbitrap with a HPLC system and LC/MS–MS system, are discussed. This case report may represent the first case of this type of intoxication and might help in improving recognition and treatment of these particular cases.

Details

Title
A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case
Author
Di Candia, Domenico 1   VIAFID ORCID Logo  ; Boracchi, Michele 1   VIAFID ORCID Logo  ; Ciprandi, Barbara 1 ; Giordano, Gaia 1   VIAFID ORCID Logo  ; Zoja, Riccardo 1   VIAFID ORCID Logo 

1  Università Degli Studi Di Milano, Dipartimento Di Scienze Biomediche Per La Salute-Sezione Di Medicina Legale E Delle Assicurazioni, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822) 
Pages
1291-1296
Publication year
2022
Publication date
Sep 2022
Publisher
Springer Nature B.V.
ISSN
09379827
e-ISSN
14371596
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s00414-022-02799-w
ProQuest document ID
2701611364
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.