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Bulletin of Experimental Biology and Medicine, Vol. 148, Suppl. 1, 2009
ULTRALOW DOSES
The Use of Anaferon (Pediatric Formulation) for Prophylaxis of Acute Respiratory Viral Infections in Preschool Children
E. I. Kondrateva, L. A. Matveeva, T. A. Shemyakina, Yu. I. Logvinenko, E. V. Golikova, and E. B. Kutuzova
Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 148, Suppl. 1, pp. 13-17, August, 2009 Original article submitted August 1, 2008
Anaferon (pediatric formulation) reduces the incidence of acute respiratory viral infections in sickly children and children with bronchial asthma and has a positive effect on the course of asthma. The preparation produces an immunomodulating effect (increases initially low IFN- levels and normalizes elevated levels of IL-1), stimulates synthesis of IgA and IgG, exhibits cytoprotective activity, and improves local immunity of the upper airways in sickly children.
Key Words: anaferon (pediatric formulation); bronchial asthma; acute respiratory viral infections; immunity
The prevalence of acute respiratory viral infections (ARVI) in children is still high; more than 75% of these cases are recorded among sickly children [7]. Children with bronchial asthma (BA) deserve special attention, because 70-90% exacerbations of the disease are related to ARVI episodes. The production of IFN is low in sickly children and children with BA [2], which dictates the necessity of using preparations modulating the immune response as the prophylactic means. Therefore, studies of a new class of drugs, inductors of endogenous IFN, are an urgent problem. Anaferon (pediatric formulation, AP) belongs to this class of preparations.
AP contains antibodies to IFN- in ultralow doses. The immunomodulating and antiviral effects of AP are related to stimulation of the synthesis of early IFN (IFN- and IFN-) and late IFN-.
Here we determined the efciency of AP for the prophylactics of ARVI in sickly children and children
with BA attending child welfare institutions during the periods of unfavorable epidemic situations.
MATERIALS AND METHODS
The study included 106 preschool children, of them 40 sickly children (kindergarten No. 81, Tomsk) and 66 children with BA (kindergarten No. 20, Seversk).
Sickly children were randomly divided into two groups. The main group 1 comprised 20 children receiving AP as the prophylactic means for 3 months (1 tablet daily, sublingually, independent of the meal). The control group 2 included 20 age-matched...