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Abstract
For an optimal initial management of chest pain [6] in ED, the Italian Society of Emergency Medicine recommend to perform a 12‑lead ECG, serial blood troponin levels, chest X-ray and eventually a cardiac stress test to exclude acute coronary syndrome (ACS) [7]. The PEPTEST™ is a medical device that works using two monoclonal anti-pepsin antibodies for detecting this enzyme, and if included into the diagnostic protocol for acute chest pain in the ED, with its rapidity and simplicity, it can guide the physician in the differential diagnosis. [...]considering the need for a further quantitative validation, the scientific community should reach a consensus for a standardized cut-off level for the diagnosis of GERD with PEPTEST™ and further studies are necessary to compare this test with others (PPI trial, esophageal pH monitoring, upper endoscopy or a combination of these tests etc.) for the diagnosis of such frequent disease.Declaration of Competing Interest The study was approved by the independent Ethics Committee of the Catholic University of Rome (ID2301) and conducted in accordance with the Declaration of Helsinki.