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Abstract
Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In fact, most patients are diagnosed or even misdiagnosed based on manifested clinical signs, as indicated by the unchanged premature mortality among gout patients over the past decade, although effective treatment is now available. An alternative, non-invasive approach for the detection of MSU crystals is X-ray dark-field radiography. In our work, we demonstrate that dark-field X-ray radiography can detect naturally developed gout in animals with high diagnostic sensitivity and specificity based on the in situ measurement of MSU crystals. With the results of this study as a potential basis for further research, we believe that X-ray dark-field radiography has the potential to substantially improve gout diagnostics.
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Details
1 Technical University of Munich, Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Garching, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
2 LMU Munich, Clinic for Birds, Small Mammals, Reptiles and Omamental Fish, Centre for Clinical Veterinary Medicine, Oberschleißheim, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
3 Technical University of Munich, Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
4 Technical University of Munich, Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966); LMU Munich, Department of Radiology, University Hospital, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
5 Technical University of Munich, Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966); Technical University of Munich, Institute for Advanced Study, Garching, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)