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Biol Trace Elem Res (2008) 124:110117
DOI 10.1007/s12011-008-8128-5
Zorica Plamenac Bulat & Danijela Djuki-osi & ivorad Malievi & Petar Bulat & Vesna Matovi
Received: 27 September 2007 /Accepted: 10 March 2008 /
Published online: 17 April 2008# Humana Press Inc. 2008
Abstract The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd groupreceived orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.
Keywords Cadmium . Zinc . Magnesium . Interactions . Blood . Organs . Rabbit
Z. P. Bulat (*) : D. Djuki-osi : V. Matovi
Institute of Toxicology Academic D. Soldatovi, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbiae-mail: [email protected]
. Malievi
Institute of Medical Research, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia
P. Bulat
Institute of Occupational Health, School of Medicine, University of Belgrade, Deligradska 29, 11000 Belgrade, Serbia
Zinc or Magnesium Supplementation Modulates Cd Intoxication in Blood, Kidney, Spleen, and Boneof Rabbits
Zn and Mg Modulate Cd Intoxication 111
Introduction
Cadmium is one of the most toxic heavy metals and serious...