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PROXIMAL PSA levels of 10 ng/mL or higher in men with biochemically recurrent prostate cancer (PCa) after radical prostatectomy and a PSA doubling time (PSADT) less than 12 months independently predicts imminent development of metastasis, according to study findings presented at the European Society for Medical Oncology 2017 Congress in Madrid, Spain.
A team led by Mark C. Markowski, MD, PhD, of Johns Hopkins University in Baltimore, studied 513 men with biochemically recurrent PCa-defined as a PSA level higher than 0.2 ng/mL after radical prostatectomy-and a PSADT less than 12 months. They defined proximal PSA as the most recent PSA value at least 6 months prior to the development of metastatic disease.
Results showed that...