Résumé/Détails

Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus

Charntikov, Sergios.   The University of Nebraska - Lincoln ProQuest Dissertations Publishing,  2015. 3689021.

Résumé (récapitulatif)

Tobacco use is the leading cause of preventable deaths worldwide. This habit is not only debilitating to individual users but also to those around them (second-hand smoking). Nicotine is the main addictive component of tobacco products and is a moderate stimulant and a mild reinforcer. Importantly, besides its unconditional effects, nicotine also has conditioned stimulus effects that may contribute to the tenacity of the smoking habit. Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated functional involvement of dorsomedial caudate putamen (dmCPu) in the conditioning processes with nicotine as a conditioned stimulus. Rats were trained using the discriminated goal-tracking task where nicotine injections (0.4 mg/kg; SC) were paired 100% of a time with intermittent (36 per session) sucrose deliveries; sucrose was not available on alternative saline days. Pre-training excitotoxic or post-training transient lesions of anterior or posterior dmCPu were used to elucidate the role of these areas in acquisition or expression of associative learning with nicotine stimulus. Pre-training lesion of p-dmCPu inhibited acquisition while post-training lesions of p-dmCPu attenuated the expression of associative learning with the nicotine stimulus. On the other hand, post-training lesions of a-dmCPu evoked nicotine like responding following saline treatment indicating the role of this area in disinhibition of learned motor behaviors. These results for the first time show the role of a- and p-dmCPu in various stages of associative learning using nicotine stimulus and provide an initial account of neural plasticity underlying these learning processes.

Indexation (données)


Sujet
Neurosciences;
Psychobiology;
Behavioral sciences
Classification
0317: Neurosciences
0349: Psychobiology
0602: Behavioral Sciences
Identificateur / mot-clé
Biological sciences; Psychology; Basal ganglia; Conditioning; Learning; Lesion; Nicotine; Striatum
Titre
Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus
Auteur
Charntikov, Sergios
Nombre de pages
103
Date du diplôme
2015
Code de l'école
0138
Source
DAI-B 76/08(E), Dissertation Abstracts International
Lieu de publication
Ann Arbor
Pays de publication
United States
ISBN
978-1-321-68019-5
Directeur de thèse
Bevins, Rick
Membre de comité
Leger, Daniel; Li, Ming; Zhou, You
Université/institution
The University of Nebraska - Lincoln
Service
Psychology
Emplacement de l'université
United States -- Nebraska
Diplôme
Ph.D.
Type de source
Thèse ou mémoire
Langue
Anglais
Type de document
Dissertation/Thesis
Numéro de la thèse/du mémoire
3689021
ID de document ProQuest
1674520523
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/unauthdocview/1674520523