摘要/索引

Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus

Charntikov, Sergios.   The University of Nebraska - Lincoln ProQuest Dissertations Publishing,  2015. 3689021.

摘要 (概要)

Tobacco use is the leading cause of preventable deaths worldwide. This habit is not only debilitating to individual users but also to those around them (second-hand smoking). Nicotine is the main addictive component of tobacco products and is a moderate stimulant and a mild reinforcer. Importantly, besides its unconditional effects, nicotine also has conditioned stimulus effects that may contribute to the tenacity of the smoking habit. Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated functional involvement of dorsomedial caudate putamen (dmCPu) in the conditioning processes with nicotine as a conditioned stimulus. Rats were trained using the discriminated goal-tracking task where nicotine injections (0.4 mg/kg; SC) were paired 100% of a time with intermittent (36 per session) sucrose deliveries; sucrose was not available on alternative saline days. Pre-training excitotoxic or post-training transient lesions of anterior or posterior dmCPu were used to elucidate the role of these areas in acquisition or expression of associative learning with nicotine stimulus. Pre-training lesion of p-dmCPu inhibited acquisition while post-training lesions of p-dmCPu attenuated the expression of associative learning with the nicotine stimulus. On the other hand, post-training lesions of a-dmCPu evoked nicotine like responding following saline treatment indicating the role of this area in disinhibition of learned motor behaviors. These results for the first time show the role of a- and p-dmCPu in various stages of associative learning using nicotine stimulus and provide an initial account of neural plasticity underlying these learning processes.

索引(详情)


主题
Neurosciences;
Psychobiology;
Behavioral sciences
分类
0317: Neurosciences
0349: Psychobiology
0602: Behavioral Sciences
标识符/关键字
Biological sciences; Psychology; Basal ganglia; Conditioning; Learning; Lesion; Nicotine; Striatum
标题
Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus
作者
Charntikov, Sergios
页数
103
学位日期
2015
学校代码
0138
来源
DAI-B 76/08(E), Dissertation Abstracts International
出版地
Ann Arbor
出版物国家/地区
United States
ISBN
978-1-321-68019-5
导师
Bevins, Rick
委员会成员
Leger, Daniel; Li, Ming; Zhou, You
大学/单位
The University of Nebraska - Lincoln
部门
Psychology
大学位置
United States -- Nebraska
学位
Ph.D.
来源类型
学位论文
语言
英语
文档类型
Dissertation/Thesis
学位论文/毕业论文编号
3689021
ProQuest 文档 ID
1674520523
版权
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/unauthdocview/1674520523