Abstrak/Detail

Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus

Charntikov, Sergios.   The University of Nebraska - Lincoln ProQuest Dissertations Publishing,  2015. 3689021.

Abstrak (ringkasan)

Tobacco use is the leading cause of preventable deaths worldwide. This habit is not only debilitating to individual users but also to those around them (second-hand smoking). Nicotine is the main addictive component of tobacco products and is a moderate stimulant and a mild reinforcer. Importantly, besides its unconditional effects, nicotine also has conditioned stimulus effects that may contribute to the tenacity of the smoking habit. Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated functional involvement of dorsomedial caudate putamen (dmCPu) in the conditioning processes with nicotine as a conditioned stimulus. Rats were trained using the discriminated goal-tracking task where nicotine injections (0.4 mg/kg; SC) were paired 100% of a time with intermittent (36 per session) sucrose deliveries; sucrose was not available on alternative saline days. Pre-training excitotoxic or post-training transient lesions of anterior or posterior dmCPu were used to elucidate the role of these areas in acquisition or expression of associative learning with nicotine stimulus. Pre-training lesion of p-dmCPu inhibited acquisition while post-training lesions of p-dmCPu attenuated the expression of associative learning with the nicotine stimulus. On the other hand, post-training lesions of a-dmCPu evoked nicotine like responding following saline treatment indicating the role of this area in disinhibition of learned motor behaviors. These results for the first time show the role of a- and p-dmCPu in various stages of associative learning using nicotine stimulus and provide an initial account of neural plasticity underlying these learning processes.

Pengindeksan (detail)


Subjek
Neurosciences;
Psychobiology;
Behavioral sciences
Klasifikasi
0317: Neurosciences
0349: Psychobiology
0602: Behavioral Sciences
Pengidentifikasi/kata kunci
Biological sciences; Psychology; Basal ganglia; Conditioning; Learning; Lesion; Nicotine; Striatum
Judul
Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus
Pengarang
Charntikov, Sergios
Jumlah halaman
103
Tanggal gelar
2015
Kode sekolah
0138
Sumber
DAI-B 76/08(E), Dissertation Abstracts International
Tempat publikasi
Ann Arbor
Negara publikasi
United States
ISBN
978-1-321-68019-5
Pembimbing
Bevins, Rick
Anggota komite
Leger, Daniel; Li, Ming; Zhou, You
Universitas/institusi
The University of Nebraska - Lincoln
Departemen
Psychology
Lokasi universitas
United States -- Nebraska
Gelar
Ph.D.
Jenis sumber
Disertasi atau Tesis
Bahasa
Inggris
Jenis dokumen
Dissertation/Thesis
Nomor disertasi/tesis
3689021
ID dokumen ProQuest
1674520523
Hak cipta
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/unauthdocview/1674520523