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As the range of assays, instruments, and user groups increases, so does the complexity of the high content screening (HCS) infrastructure needed to support it. Complexity can be greatly reduced using a central hub for images and their associated results, providing data consistency and downstream access for other analysis tools. However, setting up a hub that complements all the existing workflows is challenging. Alternative solutions often involve a high degree of manual work (e.g., moving files manually from tool to tool) or script-controlled pipelines where user influence is severely restricted. Both scenarios lead to error-prone processes, increase the administrative burden, and reduce the flexibility and scalability of the infrastructure.